Sterile Production


Sterile Filter Dryers

PSL provide sterile filter dryers from lab development to commercial production supporting globally our customer database by refining the design of our state-of-art filter dryers for more efficient aseptic manufacturing.

During aseptic processing of sterile product the substance needs to be isolated and washed in a sterile filter and dried. Utilization of the PSL Laboratory Filter Dryer will ease technology transfer from Laboratory to Kilo Lab/Pilot plant scale.

PSL Filter Dryer technology allows those steps to perform within a single vessel minimizing sterile product handling and exposure. Our filter dryers utilise double gas lift-off mechanical seals, unique off-loading designs, and innovative bellow technology, and have CIP (clean-in-place) and SIP (steam-in-place) capabilities.

Sterile Filter Dryer benefits:
  • cGMP
  • Highly efficient drying
  • Minimum gap design allowing reflux cleaning to achieve typically less than 2.5ppm to non-detectable after cleaning
  • SIP (Steam-In-Place) and CIP (Clean-In-Place)
  • Minimum solvent volumes beneath mesh for process optimisation
  • Special agitator design achieving good mixing/drying filtration even with difficult cakes
  • One piece agitator with omega wave bellow to ensure agglomeration does not occur
  • Various type of discharge available: Pressure rated discharge hatch, Glovebox, Aseptic split butterfly valve, Unique Tiltable System
  • Total interchangeability between cloth and mesh filtration media
  • New integral dust collector design for higher product yield and ease of cleaning
  • Very high levels of engineering reliability to ensure low maintenance and successful salability

Our engineering development team also developed specific sterile filter dryer designs for microsphere application. Please visit our Microsphere Formulation page or contact us for more information.

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