MSR™ – MicroSphere Refiner
FOR MICROSPHERE DEPOT FORMULATION

AT A GLANCE
Due to their characteristics and properties, polymeric microspheres have traditionally been known to be difficult to process for manufacturers – especially as the batch size gradually increases as part of the microsphere product development. The unique features of our MicroSphere Refiner were pioneered by analysing these systemic industry challenges and by better understanding microsphere processes with end-users directly in the field.
The MSR™ production system is a cGMP piece of equipment that allows drug developers and manufacturers to complete a wide range of aseptic processes with their microspheres at various scales. It is a one-of-its-kind solution that got developed and refined over decades following a Quality-by-Design (QbD) approach, taking into account the microspheres characteristics and process behaviour.

AT A GLANCE
Due to their characteristics and properties, polymeric microspheres have traditionally been known to be difficult to process for manufacturers – especially as the batch size gradually increases as part of the microsphere product development. The unique features of our MicroSphere Refiner were pioneered by analysing these systemic industry challenges and by better understanding microsphere processes with end-users directly in the field.
The MSR™ production system is a cGMP piece of equipment that allows drug developers and manufacturers to complete a wide range of aseptic processes with their microspheres at various scales. It is a one-of-its-kind solution that got developed and refined over decades following a Quality-by-Design (QbD) approach, taking into account the microspheres characteristics and process behaviour.

INDUSTRY APPLICATIONS
INDUSTRIES | PRODUCTION SCALE | PROCESSES | PRODUCT FORM | INGREDIENTS |
---|---|---|---|---|
Pharmaceuticals | Pilot development | De-watering | Suspension | API drugs |
Chemicals | Pre-clinical | Single Pass Filtration | Slurry | Polymers |
Special processes | Clinical | Loop Filtration | Wet cake | Intermediates |
Material sciences | GMP production | Re-slurry | Powder | Raw materials |
Commercial Batches | Washing | Semi-solids | Excipients | |
Sampling | Reagents | |||
Drying & Freeze-drying | ||||
Discharge |

INDUSTRY APPLICATIONS
INDUSTRIES | PRODUCTION SCALE | PROCESSES | PRODUCT FORM | INGREDIENTS |
---|---|---|---|---|
Pharmaceuticals | Pilot development | De-watering | Suspension | API drugs |
Chemicals | Pre-clinical | Single Pass Filtration | Slurry | Polymers |
Special processes | Clinical | Loop Filtration | Wet cake | Intermediates |
Material sciences | GMP production | Re-slurry | Powder | Raw materials |
Commercial Batches | Washing | Semi-solids | Excipients | |
Sampling | Reagents | |||
Drying & Freeze-drying | ||||
Discharge |

VESSEL SIZES
0.05 Model | 0.125 Model | |
---|---|---|
Typical Product Cake Volume (process-dependant) | 1.7 – 8.7L | 4.4 – 21.8L |
Maximum Liquid Volume | 151L | 188L |
Equipment Dimensions (L x W x H) | 2,720 x 2,850 x 2,760mm |

VESSEL SIZES
0.05 Model | 0.125 Model | |
---|---|---|
Typical Product Cake Volume (process-dependant) | 1.7 – 8.7L | 4.4 – 21.8L |
Maximum Liquid Volume | 151L | 188L |
Equipment Dimensions (L x W x H) | 2,720 x 2,850 x 2,760mm |

UPGRADE OPTIONS
Standard MSR™ | Upgrade Options | |
---|---|---|
De-watering Method | Suitable for Single Pass and Loop De-watering | |
Filtration Step(s) | Single Filtration (Refiner) | Dual Filtration (Scalper + Refiner) |
Drying Method | Suitable for Vacuum Drying and Freeze-Drying |

UPGRADE OPTIONS
Standard MSR™ | Upgrade Options | |
---|---|---|
De-watering Method | Suitable for Single Pass and Loop De-watering | |
Filtration Step(s) | Single Filtration (Refiner) | Dual Filtration (Scalper + Refiner) |
Drying Method | Suitable for Vacuum Drying and Freeze-Drying |
FEATURES & BENEFITS
MSR™ SERVICES
At PSL, we provide our industry partners with more than just process hardware. We take your process further together by offering a wide range of services to optimise the installation, operation and maintenance of your PSL MSR™.
By opting for our unique COPE and SERVE services, you can rest assured that you will receive and maintain a high-performing MSR™ production system, fine-tuned to your unique process requirements.
RESOURCES

HOW CAN PSL HELP WITH YOUR NEXT PROJECT?
Contact us to see how PSL can assist on your next project or if you simply have a question for us. A PSL representative will respond within one working day.
HOW CAN PSL HELP WITH YOUR NEXT PROJECT?
Contact us to see how PSL can assist on your next project or if you simply have a question for us. A PSL representative will respond within one working day.